human ovarian cancer cell line skov 3 (CLS Cell Lines Service GmbH)
CLS Cell Lines Service GmbH is a verified supplier 
CLS Cell Lines Service GmbH manufactures this product 
94
Structured Review
CLS Cell Lines Service GmbH
human ovarian cancer cell line skov 3
Human Ovarian Cancer Cell Line Skov 3, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 94/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cell+lines/SK-OV-3+Cells/pmc13691625-47-1-13
Average 94 stars, based on 16 article reviews
Human Ovarian Cancer Cell Line Skov 3, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 94/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cell+lines/SK-OV-3+Cells/pmc13691625-47-1-13
Average 94 stars, based on 16 article reviews
human ovarian cancer cell line skov 3 - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "Identifying Drug‐Induced Metabolic Signatures in Comparative Untargeted NMR Metabolomics Using Difference Spectra"
Article Title: Identifying Drug‐Induced Metabolic Signatures in Comparative Untargeted NMR Metabolomics Using Difference Spectra
Journal: Bioinorganic Chemistry and Applications
doi: 10.1155/bca/9636071
Figure Legend Snippet: Principal component analysis (PCA) of the NMR profiles. (A) PCA score plots derived from Bspectra of treated cell lysates (left, proportion of variance: PC1 (0.528), PC2 (0.276)) and respective growth media (right, proportion of variance: PC1 (0.985), PC2 (0.0068)). (B) PCA score plots of average Bdifference_spectra of cell lysates (left, proportion of variance: PC1 (0.786), PC2 (0.088)) and growth media (right, proportion of variance: PC1 (0.991), PC2 (0.0048)). (C) PCA score plot of concatenated average Bdifference_spectra (cell lysates + growth media); proportion of variance: PC1 (0.866), PC2 (0.0923). Symbols indicate cell lines: A2780 (circles) and SKOV‐3 (diamonds). Colors indicate treatment: AF (blue); AuTM (red); CN1 (green); and CN2 (yellow).
Techniques Used: Analysis, Derivative Assay, Nuclear Magnetic Resonance
Figure Legend Snippet: Cluster cohesion analysis of PCA derived from NMR profiles. PCA score plots derived from (A) Bspectra of treated cell lysates; (B) Bspectra of treated growth media; (C) concatenated average Bdifference_spectra (cell lysates + growth media). In each score plot, the cluster centroids are shown as black‐contoured large dots; the respective average silhouette width ( s ) and p values from the permutation tests on centroid distances ( p ) are also reported.
Techniques Used: Analysis, Derivative Assay
Figure Legend Snippet: Comparative analysis of metabolic dysregulation induced by the four selected gold(I) compounds and AF‐analogs. (A) Bar plots representing the dysregulation indices (average ± sd) for AF, AuTM, CN1, and CN2 in A2780 (left) and SKOV‐3 (right) cells. (C) Bar plots of the dysregulation indices (average ± sd) for all compounds in A2780 cells. Colors indicate treatments: AF (blue); AuTM (red); CN1 (green); CN2 (yellow); and AF‐analogs (AFCl, AFI, (Ph 3 P)AuI) shown as shades of blue.
Techniques Used: Analysis
Figure Legend Snippet: Dot plots of the pathway analysis results for the different treatments in A2780 and SKOV‐3 cells. Each enriched pathway is represented as a dot with color intensity and size reflecting the weighted average of the absolute values of the log2(FC) for the detected metabolites within each pathway, using metabolite importance as a weight. For each treatment and cell line, the pathway with the highest FC value was set to 100, and all other pathways were scaled proportionally.
Techniques Used: Analysis
Figure Legend Snippet: Integrated pathway and metabolite analysis of AF‐induced metabolic changes. (A) Sankey diagram showing the five most dysregulated pathways shared between A2780 and SKOV‐3 cells upon AF treatment, together with the associated metabolites. (B) Box plots of relative metabolite concentrations in the intracellular compartment (cell lysates, L). Intracellular levels of glutathione, glutamate, and glycine are shown for control (blue) and AF‐treated (cyan) A2780 and SKOV‐3 cells.
Techniques Used: Analysis, Control
Related Articles
Pathology:Article Title: Effects of Soft Denture Liners on L929 Fibroblasts, HaCaT Keratinocytes, and RAW 264.7 Macrophages Article Snippet: They were individually placed on 24-well plates with 3 mL of Dulbecco's modified Eagle medium (DMEM—Sigma Chemical Co., St. Louis, MO, USA) with antibiotics (Gibco, Grand Island, NY, USA) in each well and incubated at 37°C with 5% CO 2 and 95% air for 24 or 48 h. Culture medium without test specimens was also incubated under the same conditions and served as control. .. The three immortalized Cell Culture:Article Title: Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices Article Snippet: .. All Article Title: Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices. Article Snippet: .. Modification:Article Title: Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices Article Snippet: .. All Article Title: Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices. Article Snippet: .. other:Article Title: The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma Article Snippet: Pretrials were performed with Article Title: RAC1 -Amplified and RAC1 -A159V Hotspot-Mutated Head and Neck Cancer Sensitive to the Rac Inhibitor EHop-016 In Vivo: A Proof-of-Concept Study Article Snippet: The PDCs were free of mycoplasma and free of cellular contamination from commercial Activity Assay:Article Title: Decrease of ESKAPE virulence with a cationic heme-mimetic gallium porphyrin photosensitizer: The Trojan horse strategy that could help address antimicrobial resistance. Article Snippet: .. To assess the changes in the activity of toxin A the |
![Recordings were made on a Qube 384 automated patch-clamp instrument (Sophion Bioscience) using a stable cell line with human Nav1.7 channels expressed in <t>HEK293</t> cells using 10-hole recording wells. Sodium channel current was evoked by a step from –80 mV to +5 mV delivered every 3 s. Each concentration of AM-2099 was applied in 16 wells, and data from each well were accepted if the leak-corrected current at the holding voltage of –80 mV was less than 0.5 nA and the peak sodium current in control was >10 nA. Symbols show mean ± SD for wells meeting these criteria with current measured after 16 min of exposure to compound. ( A ) 12 wells for control solution containing 0.1% DMSO (0 nM), 8 for 1 nM, 8 for 3 nM, 8 for 10 nM, 8 for 30 nM, 8 for 100 nM, 12 for 300 nM, and 15 for 1000 nM. ( B ) 23 wells for control drug-free solution containing 0.1% DMSO, 12 for 1 nM, 13 for 3 nM, 15 for 10 nM, 9 for 30 nM, 11 for 100 nM, 11 for 300 nM, and 15 for 1000 nM. Fitted curves: Imax/(1+[Drug]/Kd), where Imax was fixed at the average value in the DMSO control wells (concentration of 0 nM) and the fit included weighting of data points by SD. Fit to data in (A) ignored the values from the column corresponding to 3 nM AM-2099 as it was obvious that there was an error in preparing this dilution. Internal solution (mM):140 CsF, 10 NaCl, 1 EGTA, 10 HEPES, 25 sucrose pH 7.3 w CsOH. External Solution (mM):145 NaCl, 4 KCl, 2 CaCl 2 , 1 MgCl 2 , 10 HEPES, 10 glucose, pH 7.4 w NaOH. All solutions contained 1 mg/mL Pluronic-F68. Figure 1—source data 1. Numerical data contained in .](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_4097/pmc13694097/pmc13694097__elife-111490-fig1.jpg)
